• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to an injection device (1) for the simultaneous delivery of several drugs. The injection device (1) comprises a support housing (5), an activation sleeve (8) surrounding the support housing (5), at least two carpules (9, 11), a first drive assembly (13) for delivering the medicaments, a securing device (14). a needle assembly (17), a needle guard (20), and a second triggerable drive assembly (21) for the needle assembly (17). The carpules (9, 11) are arranged side by side in cross-section. The first drive assembly (13) has a drive element (22) with one of the number of cartridges (9, 11) the same number of piston rods (23, 24), which form a related assembly. At least one of the piston rods (23, 24) has a hollow cylindrical shape and is designed to be closed on the piston side, a first drive means (26) of the first drive assembly (13) being arranged inside the same. The first drive means (26) can be arranged in a receiving part (27) of the drive element (22) arranged laterally next to the piston rods (23, 24), the receiving part (27) being associated with the piston rods (23, 24) Building unit.
    公开号:AT519383A1
    申请号:T50987/2016
    申请日:2016-10-27
    公开日:2018-06-15
    发明作者:
    申请人:Pharma Consult Gmbh；
    IPC主号:
    专利说明:

    Summary
    The invention relates to an injection device (1) for the simultaneous dispensing of several medicaments. The injection device (1) comprises a support housing (5), an activation sleeve (8) surrounding the support housing (5), at least two cartridges (9, 11), a first drive assembly (13) for dispensing the medication, a safety device (14) , a needle arrangement (17), a needle protection element (20) and a second triggerable drive assembly (21) for the needle arrangement (17). The carpules (9, 11) are arranged side by side as seen in cross section. The first drive module (13) has a drive element (22) with a number of piston rods (23, 24) which is the same as the number of cartridges (9, 11) and which form an associated structural unit. At least one of the piston rods (23, 24) has a hollow cylindrical shape and is closed on the piston side, a first drive means (26) of the first drive assembly (13) being arranged within the piston rod. The first drive means (26) can be arranged in a receiving part (27) of the drive element (22) arranged laterally next to the piston rods (23, 24) in cross section, the receiving part (27) being associated with the piston rods (23, 24) Training unit.
    Fig. 6
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    The invention relates to an injection device, in particular an auto-injector, for simultaneously dispensing at least two medications.
    WO 2009/152542 A1 discloses a generic injection device with a distal end section and a proximal end section. Starting from a storage position, the injection device is automatically adjustable into an injection position and comprises a sleeve-shaped support housing, which is divided into a front support housing part and a rear support housing part, and has a distal end and a proximal end. The largest part of the length of the support housing is surrounded by an activation sleeve, the distal end of the support housing projecting beyond the activation sleeve. The activation sleeve is adjustable relative to the support housing in the axial direction to trigger the injection device. A carpule and a needle arrangement are arranged in the support housing. The carpule is in drive connection with a first drive module. The position of the first drive assembly is fixed by means of a securing device until it is activated for the injection process with respect to the support housing. Furthermore, a needle arrangement with a cannula is accommodated within the carrying housing, the needle arrangement being arranged upstream of the carpule in the section of the distal end in the storage position of the injection device. Both cannula ends of the cannula are also arranged within the carrying housing. Furthermore, a needle protection element is provided with a second, releasable drive assembly which is connected to the drive and which shifts the needle protection element from the inactive position to the covering position. The first drive assembly is seen in the axial direction,
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    N2016 / 28700-AT-00 arranged behind the carpule, which requires an increased space in the direction of the longitudinal extent.
    The object of the present invention was to overcome the disadvantages of the prior art and to provide an injection device which enables a multiple arrangement of cartridges and, moreover, also enables a compact construction of the entire injection device.
    This object is achieved by an injection device according to the claims.
    The injection device according to the invention, in particular the auto-injector, serves for the simultaneous delivery of at least two medications to a living being, in particular a person, who is or is in an emergency or an exceptional situation. The injection device designed here as an auto-injector can be automatically adjusted into an injection position starting from a storage position. Furthermore, the injection device has a distal end section which can be turned towards a person and a proximal end section which is turned away from it and comprises a support housing which is designed in the form of a sleeve and has a distal end and a proximal end, an activation sleeve, which activation sleeve the support housing for a major part of its longitudinal extent starting from the proximal end in the direction of the distal end, the distal end of the support housing projecting beyond the activation sleeve, and the activation sleeve being adjustable in the axial direction relative to the support housing, at least one carpule with a piston arranged therein and adjustable in the axial direction and with a medication received in the at least one cartridge and to be dispensed during the injection process, the at least one cartridge being accommodated in the carrier housing, a first drive assembly with a first drive means, which he first drive assembly is in drive connection with the at least one carpule and the first drive assembly can be triggered by means of the activation sleeve,
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    N2016 / 28700-AT-00 a securing device, which securing device defines the position of the first drive assembly until it is activated for the injection process with respect to the supporting housing, a needle arrangement with at least one cannula, which needle arrangement in the storage position of the injection device of the at least one carpule in the section is arranged upstream of the distal end and in each case both cannula ends of the at least one cannula are arranged within the support housing, a needle protection element, which needle protection element can be displaced from a release position in the storage position to a cover position, in which cover position that which projects beyond the distal end of the support housing after the injection process Needle end of the at least one cannula is covered, a second triggerable drive assembly with a second drive means, which second drive assembly removes the needle protection element from the inactive position relocated to the cover position, and that at least two carpules are provided and the at least two carpules are arranged side by side in the support housing, as seen in cross-section, that the first drive assembly further has a drive element, which drive element is arranged within the support housing, that the drive element in each case one of the Number of cartridges has the same number of piston rods and the piston rods form an associated structural unit, that at least one of the piston rods is hollow-cylindrical and is closed on its first end region facing the distal end section, that the first drive means in the at least one hollow-cylindrical piston rod and / or that the first drive means is arranged in a receiving part of the drive element arranged laterally next to the piston rods in cross section, and the receiving part is associated with the piston rods e training unit.
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    The advantage achieved thereby is that by providing the drive element as part of the drive assembly and due to the multiple arrangement of cartridges next to one another, the drive means of the first drive assembly can be arranged directly inside one of the hollow cylindrical piston rods and / or immediately to the side of them. Due to the possible arrangement of the drive means within at least one of the piston rods, a shorter, compact design of the injection device can be achieved. If the first drive means is accommodated in a separate receiving part arranged laterally next to the piston rods, a certain overall length can also be saved in spite of the multiple arrangement of carpules. By forming a separate drive element on which both the piston rods and optionally also laterally next to the piston rods a separate receiving part for the first drive means is provided, a compactly designed first drive assembly can be formed. In addition, however, an assembly that is completely closed on the outside is also created, outside of which none of the first drive means is arranged. This makes the necessary sterilization easier and safer.
    Furthermore, it can be advantageous if each of the at least two cartridges is preceded by its own cannula. This means that standard components can be used. In addition, however, there is the possibility of choosing different cannula lengths for the medication to be dispensed in order to be able to easily determine the depth of penetration and thus the delivery site below the skin surface.
    Another embodiment is characterized in that the drive element has a connecting part, by means of which connecting part the piston rods and the receiving part are connected to one another in their second end regions facing the proximal end section and the piston rods and the receiving part protrude from the connecting part in the distal direction. By providing the additional connecting part, a compact construction can thus be achieved
    N2016 / 28700-AT-00 can be created. In addition, however, the mutual arrangement of the carpules relative to one another is also simplified, in particular when different carpule sizes are to be arranged next to one another.
    A further possible embodiment has the features that the piston rods and the receiving part are each designed as hollow cylinders and are each closed in their first end regions facing the distal end section. Material can thus be saved and, moreover, an outer surface that is completely closed starting from the proximal end to the distal end can be formed.
    Furthermore, it can be advantageous if only one of the pistons of a first of the at least two cartridges is coupled to the piston rod assigned to the piston and the other of the at least two cartridges is held on the first carpule by means of a holding device. By coupling the piston rod to the piston, the two carpules can be held resiliently on the drive element in the event of a load occurring in the event of a fall. In the storage position, the drive element is also held positioned relative to the support housing, so that the carpules can also be positioned.
    A further possible and possibly alternative embodiment has the features that each of the pistons is coupled to the piston rod assigned to it and the at least two carpules are held independently of one another on the drive element. Each of the cartridges can thus be held independently of one another on the common drive element on the piston rods arranged there. In this way, an even more individual flexibility can be achieved when the cartridges are held within the carrier housing.
    A further embodiment provides that the carrier housing comprises a front carrier housing part with a front receiving space and a rear carrier housing part with a rear receiving chamber, and the two carrier housing parts in a connecting section in the axial direction in two different longitudinal positions in a first connecting position and a second connecting position
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    N2016 / 28700-AT-00 can be coupled together. The subdivision of the support housing into the two support housing parts thus creates a simple possibility of firstly allowing access to the largely enclosed interior for the sterilization to be carried out and then, after sterilization, being able to completely seal off the previously sterilized interior from the external environment. As a result, all of the components arranged within the carrier housing can be kept sterile until the injection device is used.
    Another embodiment is characterized in that the two support housing parts can be coupled to one another in the connecting section via a coupling device. This allows additional guidance to be created between the housing parts to be coupled. Furthermore, a secure positional positioning of the two support housings relative to one another can also be achieved in at least one of the two connecting positions, in particular in both of the connecting positions.
    A further preferred embodiment is characterized in that the rear support housing part has at least two guide extensions projecting in the distal direction, which guide extensions are supported on the front support housing part. By providing additional guide extensions, a better and tilt-free adjustment movement between the two connecting positions of the two support housing parts can be made possible. Furthermore, in the first connection position between the guide extensions, access to the receiving space of the support housing can also be created.
    Furthermore, it can be advantageous if the support housing parts in the first connection position have a greater longitudinal extension than the second connection position. A clear relative positional positioning relative to one another can thus be achieved between the two support housing parts. Furthermore, it can also be used to create a gap between the two supporting housing parts in the larger longitudinal extent so that the receiving space can be sterilized.
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    Another alternative embodiment is characterized in that the front support housing part has a longitudinal extent in the axial direction, which has a value range with a value with a lower limit of 60% and a value with an upper limit of 95%, in particular with a value with a lower limit of 70% and a value with an upper limit of 85%, based on the total longitudinal extent of the two support housing parts is selected in their second connection position. In this way, the receiving space for sterilization within the support housing can be significantly extended in the direction of the rear support housing part. In addition, since a sealing element is provided in the connection area between the two support housing parts, the sealing of the receiving space can also be shifted towards the drive element. Since the common drive element in the storage position is held in a positioned position on the support housing, in particular the rear support housing part, no relative adjustments can be made between the sealing element and the common drive element even when shocks occur, and so contamination, in particular germs, enter the sterilized receiving space ,
    A further possible and possibly alternative embodiment has the features that the distal end of the support housing, in particular the distal end of the front support housing part, has a number of openings equal to the number of cannulas, which openings allow the distal cannula ends of the cannulas of the needle arrangement to pass through. and a pierceable sealing plug is arranged in the sealing position in each of the openings. In this way, a separate passage area to be sealed can be created for each of the cannulas, which additionally enables a complete seal into the receiving space.
    A further embodiment provides that a sealing element is provided, which sealing element is arranged between the front support housing part and the rear support housing part and is designed to run continuously over the circumference. By
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    N2016 / 28700-AT-00 the provision of the sealing element can thus prevent contamination, in particular germs, from entering the sterilized receiving space after the receiving space has been sterilized.
    Another embodiment is characterized in that the sealing element on its distal end section facing the front support housing part has a sealing attachment which extends over the entire circumference, which sealing attachment is arranged spaced apart from an end face of the front support housing part in the first connecting position of the two support housing parts and the sealing attachment in the second connection position of the two support housing parts rests sealingly on the end face of the front support housing part. The provision of the sealing attachment allows a simple sealing effect to be created on end faces which are preferably of flat surface between the two support housing parts.
    A further preferred embodiment is characterized in that the sealing attachment of the sealing element is supported on an end face of the rear support housing part facing the front support housing part and the sealing element also extends adjacent to the rear support housing part. This can provide secure support for the sealing element for the relative adjustment process between the two support housing parts. Furthermore, a secure positional fixation of the sealing element can also be made possible in the second connecting position of the two support housing parts.
    Furthermore, it can be advantageous if the sealing element in the storage position and when the support housing parts are in the second connection position rests on the rear support housing part as well as on the drive element arranged within the latter, in particular its connection part, of the first drive assembly in a fully circumferential manner. In this way, an all-round sealing seat between the drive element and the support housing, in particular the rear support housing part, can be created in the region of the rear support housing part.
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    N2016 / 28700 AT-00
    Another embodiment is characterized in that the support housing, in particular the rear support housing part, has at its distal end a transverse wall with a locking recess arranged therein. A secure locking position and a relative positioning to one another can thus be created for the securing device, part of which is arranged on the common drive element.
    A further possible embodiment has the features that the securing device comprises at least one retaining hook, which is arranged at least one retaining hook on the drive element, in particular its connecting part, and the at least one retaining hook is held in the locking position of the transverse wall in the storage position. It is thus possible to dispense with the provision of additional retaining elements and thus to provide a compactly designed drive element which is arranged in the storage position in the immediate vicinity of the proximal end of the carrying housing.
    A further embodiment provides that the securing device has a securing cap arranged in the distal end section with a securing pin, and the securing pin holds the at least one retaining hook in a locked position in the storage position. Unintentional triggering can be prevented by providing the safety cap with the safety pin.
    Another embodiment is characterized in that the activation sleeve has an end wall in its proximal end region, on which end wall a release means, in particular a release opening, is arranged, which release means is aligned in the axial direction with respect to those in the transverse wall of the support housing, in particular the rear support housing part. arranged locking recess is aligned. The provision of the triggering means allows the automated dispensing process to be initiated after the safety device has been triggered when the activation sleeve is actuated.
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    A further preferred embodiment is characterized in that the second drive means of the second drive assembly is arranged outside of the support housing, in particular outside of the two support housing parts, and within the activation sleeve. A protected arrangement of the second drive means can thus be created. In addition, manipulations can be prevented safely.
    Furthermore, it can be advantageous if the second drive means of the second drive assembly extends in the axial direction between the needle protection element and the proximal end of the support housing, in particular the rear support housing part. Due to the relatively long axial extent of the second drive means, the latter can be made slim.
    Furthermore, it can be advantageous if the first drive means and / or the second drive means are each formed by a compression spring designed as a helical spring. This means that commercially available and inexpensive components can be used. Furthermore, the adjustment force built up by the respective springs can also be easily adapted to the respective operating conditions.
    Another alternative embodiment is characterized in that the second drive means is arranged on the side of the piston rods opposite the receiving part of the drive element in cross section. This also allows a laterally offset arrangement of the second drive means within the injection device. This is also favored by the fact that the cross-sectional shape of the support housing is adapted to the cylindrical carpules and so a certain longitudinal guidance is already formed on the outside of the support housing.
    A further possible and possibly alternative embodiment has the features that the second drive means is guided in its longitudinal extent at least in sections by means of guide elements, the guide elements on an outside of the support housing, in particular the front support 11/39
    N2016 / 28700-AT-00 housing part, are arranged. In this way, buckling of the second drive means and thus tilting of the same between the support housing and the release sleeve can be avoided.
    A further embodiment provides that the needle protection element is held locked in its covering position in the proximal direction and in the axial direction relative to the support housing. This can prevent a puncture injury from the cannula ends of the cannulas that have already been used and thus the transmission of infections.
    Another embodiment is characterized in that the axial adjustment of the activation sleeve relative to the support housing results in the simultaneous release of both the first drive assembly and the second drive assembly. In this way, both the delivery of the medication and the subsequent protective position of the needle protection element can be ensured without any action on the part of the person.
    For a better understanding of the invention, this will be explained in more detail with reference to the following figures.
    Each show in a highly simplified, schematic representation:
    Figure 1 shows the injection device in a diagrammatic representation, in its secured storage position.
    FIG. 2 shows the injection device according to FIG. 1 in a diagrammatic representation, but with the activation sleeve removed;
    3 shows the injection device according to FIGS. 1 and 2, in a separate arrangement of the components;
    4 shows the injection device according to FIG. 2 in a diagrammatic illustration, in a view of the second drive assembly for the needle protection element;
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    5 shows the injection device according to FIG. 1 in its secured storage position, in axial section through the carpules;
    6 shows the injection device according to FIG. 5, after delivery and with the needle protection element in the protective position;
    FIG. 7 shows the injection device according to FIG. 5, in cross section according to the lines VII-VII in FIG. 5;
    8 shows the proximal end section of the injection device, in the sterilization position in axial section through the securing device.
    In the introduction, it should be noted that in the differently described embodiments, the same parts are provided with the same reference numerals or the same component names, and the disclosures contained in the entire description can be applied analogously to the same parts with the same reference numerals or the same component names. The location information selected in the description, e.g. above, below, to the side, etc., referring to the figure described and illustrated immediately, and if the position is changed, these are to be applied accordingly to the new position.
    The term “in particular” is understood in the following to mean that this may be a more specific training or more detailed specification of an object or a method step, but does not necessarily have to represent a mandatory, preferred embodiment of the same or a mandatory procedure.
    1 to 8 show an injection device 1 in various views and sections, which can also be referred to as an auto-injector. Such auto-injectors serve to indicate at least one medicament to a person 2 or a living being, the dispensing being automatic and therefore automatic without the intervention of the administering person. Injection devices 1 of this type are secured in their storage position against unwanted triggering, the triggering or actuation taking place only by deliberate release or unlocking of a safety device 14 described below
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    N2016 / 28700-AT-00 can. Once the release has taken place, the triggering or actuation can take place, as a result of which the injection device 1 is automatically set to an injection position and in which the stored medication or medications are dispensed.
    In some applications, it may be necessary to provide several medications separately from one another in the injection device 1 without these coming into contact with one another before delivery. The injection device 1 described below is provided for such a purpose. At least two medications are to be stored, which are to be dispensed to person 2 at one time.
    The injection device 1 has a distal end section 3 which can be turned towards the person 2 and a proximal end section 4 which is turned away from it. Individual component groups or components of the injection device 1, which may include these, are described below. Furthermore, the designation for the location information is used at the front and rear and is assigned to the distal end section 3 at the front and the proximal end section 4 at the rear.
    The injection device 1 thus comprises a support housing 5 which is sleeve-shaped and has a distal end 6 and a proximal end 7. Furthermore, an activation sleeve 8 is provided, which for a major part of its longitudinal extent surrounds the support housing 5, starting from the proximal end 7 in the direction of the distal end 6. The distal end 6 of the support housing 5 projects beyond the activation sleeve 8 in the distal direction. Furthermore, the activation sleeve 8 is guided relative to the support housing 5 so that it can be adjusted in the axial direction. This relative stroke serves, as will be described later, for the release and associated dispensing of the medication or medications.
    In the present exemplary embodiment, two cartridges 9, 11 are received or arranged in the carrier housing 5 with the medication to be dispensed in each case, but not described in more detail. As is known, within each of the cartridges 9, 11 there is a piston 10, 12 for sealingly closing the cartridges 9, 11 therein
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    N2016 / 28700-AT-00 proximal end areas. The cartridges 9, 11 are connected to a first drive assembly 13 for the delivery of the medication. The at least two carpules 9, 11 are arranged side by side in the support housing 5, as seen in cross section. The activation or triggering of the drive assembly 13 can take place after the safety device 14 has been released by means of the activation sleeve 8.
    The securing device 14 fixes at least the first drive assembly 13 in position until it is activated for the injection process with respect to the support housing 5.
    Furthermore, it can be advantageous if a separate cannula 15, 16 is provided for each of the cartridges 9, 11. The cannulas 15, 16 form a needle arrangement 17. The needle arrangement 17, in particular its cannulas 15, 16, are arranged in the storage position of the injection device 1 of the respective carpule 9 in the section of the distal end 7. Each of the cannulas 15, 16 in turn has cannula ends 18, 19, both of the cannula ends 18, 19 being also arranged in the storage position within the carrying housing 5. In the storage position, the proximal cannula ends 19 of the cannulas 15, 16 of the respective carpule 9, 11 are also arranged upstream. The puncture and thus the access to the medicament is only created by the activation sleeve 8 when the injection device 1 is activated.
    To cover the distal cannula ends 18 protruding beyond the carrier housing 5 after the medication has been dispensed, a needle protection element 20 can also be provided. If the injection device 1 is in the storage position, the needle protection element 20 is arranged in a so-called release position for the distal cannula ends 18, in which the unimpeded adjustment of the cannulas 15, 16 and the subsequent delivery can take place. If the dispensing process has begun and the distal cannula ends 18 are still in their puncture position, which is inserted into the person 2, the needle protection element 20 can be in a position which rests against the skin or on a garment of the person 2. For the automated adjustment of the needle 15/39
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    Protective element 20, a second triggerable drive assembly 18 can be provided, which is in drive connection with the needle protective element 20. This makes it possible to move the needle protection element 20 after the injection process via the distal cannula ends 18 protruding from the support housing 5 via the distal end 7 into a protective position that protects them.
    The drive assembly 13 can also have a drive element 22, which is also arranged within the support housing 5. The drive element 22 has in each case one of the number of cartridges 9, 11 of the same number of piston rods 23, 24, the piston rods 23, 24 forming an associated structural unit.
    Furthermore, it is possible for at least one of the piston rods 23, 24 to have a hollow cylindrical shape and to be closed in its first end region 25 facing the distal end section 3. In this case, depending on the clear internal dimension of the piston rod 23, 24, it would be possible to arrange or accommodate a first drive means 46 of the first drive assembly 13 in the at least one hollow cylindrical piston rod 23, 24.
    In addition or independently of this, it would also be possible to provide a separate receiving part 27 on the drive element 22, which is seen laterally next to the piston rods 23, 24 in cross section and to arrange or receive the first drive means 26 therein. However, a multiple arrangement of first drive means 26 could also be provided, in which a first drive means 26 is located both within at least one of the piston rods 23, 24 and the receiving part 27.
    If the receiving part 27 is provided, it forms an associated structural unit with the piston rods 23, 24. Furthermore, the drive element 22 can also have a connecting part 28, by means of which the at least two piston rods 23, 24 and, if provided, also the receiving part 27 are connected to one another to form a structural unit. Each of the piston rods 23, 24 and, if provided, also the receiving part 27 each have second end regions 29
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    N2016 / 28700-AT-00, the mutual connection to the structural unit taking place in the region of the second end regions 29. Starting from the common connecting part 28, the at least two piston rods 23, 24 and optionally the receiving part 27 project in the distal direction thereof.
    In order to save material and weight, it may be advantageous if the at least two piston rods 23, 24 and the receiving part 27 of the drive element 22 are each designed in the shape of a hollow cylinder and are each closed in their first end regions 25 facing the distal end section 3.
    There are different possibilities for holding the cartridges 9, 11 on the drive element 22. The first possibility provides for coupling only one of the pistons 10, 12 of a first of the at least two cartridges 9, 11 to the piston rod 23, 24 assigned to the piston 10, 12 and bringing them into drive connection. The further of the at least two carpules 11, 9 is held on the first of the at least two carpules 9, 11 by means of a holding device 30. The non-coupled other piston rod 24, 23 only serves to propel the carpule 11 and the piston 12 arranged therein.
    In a possible second arrangement, it is provided that each of the pistons 10, 12 is coupled to the piston rods 23, 24 assigned to the pistons and that the at least two carpules 9, 11 are held independently of one another on the drive element 22.
    In order to facilitate the assembly and the sterilization of components arranged within the carrier housing 5, the carrier housing 5 is divided into a front carrier housing part 31 and a rear carrier housing part 32. The front support housing part 31 delimits a front receiving space 33, a rear receiving space 34 being delimited by the rear support housing part 32. For mutual connection, the two support housing parts 31, 32 are in a connecting section 35 in the axial direction in two different longitudinal positions in a first connecting position and a second connecting position
    N2016 / 28700-AT-00 which can be coupled. This can be done by means of a coupling device 36, not shown in detail. The support housing parts 31, 32 thus have a greater longitudinal extent in the first connection position with respect to the second connection position.
    In the present exemplary embodiment, the front support housing part 31 has a longitudinal extent in the axial direction, which in a value range with a value with a lower limit of 60% and a value with an upper limit of 95% based on the total longitudinal extent of the two support housing parts 31, 32 in whose second connection position is selected. However, a range of values has also been found to be favorable, in which a value with a lower limit of 70% and a value with an upper limit of 85% is selected in relation to the total longitudinal extent of the two support housing parts 31, 32 in their second connection position.
    Furthermore, it is also shown that the rear support housing part 32 can have at least two guide extensions 37 projecting in the distal direction. However, it would also be possible to provide the guide extensions 37 either only on the front support housing part 31 or alternately. The guide extensions 37 are supported on the front support housing part 31 and / or on the rear support housing part 32.
    In order to avoid unwanted access of dirt to the cannulas 15, 16 and the cartridges 9, 11 during the storage position, it is also provided that the distal end 7 of the support housing 5, in particular the distal end 7 of the front support housing part 31, one of the Number of cannulas 15, 16 has the same number of openings 38. Since the number of cannulas 15, 16 is preferably chosen to be equal to the number of cartridges 9, 11, this also corresponds to the number of openings 38. In the individual openings 38, a pierceable sealing plug 39 is arranged in a sealing position, of which openings 38 passage of the distal cannula ends 18 of the cannulas 15, 16 is made possible. When dispensing, the sealing plugs 39 are also pierced by the cannulas 15, 16.
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    For the mutual sealing between the two facing ends of the two supporting housing parts 31, 32, a sealing element 40 is also provided, which is formed continuously over the circumference. The sealing element 40 has, on its distal end section facing the front support housing part 31, a sealing projection 41 which extends over the entire circumference. Furthermore, the preferably flange-shaped sealing projection 41 can be designed such that it projects between facing end faces 42, 43 of the two support housing parts 31, 32 - see FIG. 8. In the first connection position described above, between the facing end faces of the two support housing parts 31, 32 a circumferential gap is also formed. In which the sealing projection 41 can also protrude. In order to provide at least one access for carrying out the sterilization by means of a gassing process into the front receiving space 33 of the front support housing part 31, the gap width is to be chosen so large that the gap is not completely closed by the sealing attachment 41 located therein.
    In this exemplary embodiment it is provided that in the first connecting position of the two support housing parts 31, the sealing projection 41 is arranged at a distance from the end face 42 of the front support housing part 31. In the second connecting position of the two support housing parts 31, 32, the sealing shoulder 41 lies sealingly against the end face 42 of the front support housing part 31. Furthermore, the sealing projection 41 of the sealing element 40 can be supported on the end face 43 of the rear support housing part 32 facing the front support housing part 31. The circumferential sealing element 40 can also extend into the rear support housing part 32 and be supported against the inner surface thereof.
    It is also essential that the sealing element 40 in the storage position and when the support housing parts 31, 32 are in the second connecting position also bears against the drive element 22 arranged within the sealing element in a completely circumferential manner. A circumferential support of the sealing element 40 is preferably also provided on the inner surface of the rear support housing part 32
    N2016 / 28700-AT-00 hen. In any case, at least the front receiving space 33 in the storage position must be completely sealed off from the external environment by means of the sealing element 40. The sealing element 40 is sealed against the outer circumference of the connecting part 28 of the drive element.
    The securing device 14 comprises at least one, preferably a plurality of retaining hooks 44, which or which at least one retaining hook 44 is or are arranged on the drive element 22. For this purpose, the connecting part 28 of the drive element 22 has an end wall which is preferably oriented in the vertical direction with respect to a longitudinal axis 45 of the injection device 1 and of which the at least one retaining hook 44 is arranged so as to protrude in the proximal direction. For the latching engagement of the at least one retaining hook 44, the carrier housing 5, in particular the rear carrier housing part 32, can have at its distal end a transverse wall 46 with a latching recess 47 arranged therein. The at least one retaining hook 44 can thus be held in the securing position and the storage position in the locking recess 47 of the transverse wall 46. In this position, the at least one retaining hook 44 engages behind the transverse wall 46 on its side facing the proximal end section 4. The first drive means 26 is supported on the one hand on the rear support housing part 32 and in the receiving part 27 under pretension. If the securing device 14 is unlocked, the drive element 22 is displaced in the direction of the distal end 6 or the distal end section 3.
    Furthermore, the securing device 14 can have a securing cap 48 with a securing pin 49 arranged in the proximal end section 4 of the injection device 1. This securing pin 49 holds the at least one retaining hook 44 in the locked position on the support housing 5 in the storage position. To unlock or release the at least one retaining hook 44, this must first be released by the locking pin 49.
    The activation and associated with this the release of the at least one retaining hook 44 takes place by means of the activation sleeve 8. For this purpose, this has an end wall 50 in its proximal end region. On the end wall 50 is a
    20/39
    N2016 / 28700 AT-00
    Trigger means 51 is provided, which in this embodiment is designed as a trigger opening. The triggering means 51 is aligned in the axial direction with respect to the latching recess 47 arranged in the transverse wall 46 of the support housing 5, in particular the rear support housing part 32.
    The needle protection element 20 is in drive connection with the second drive assembly 21 - see FIG. 4. The second drive assembly 21 comprises at least one second drive means 52, which is arranged outside the support housing 5, in particular the two support housing parts 31, 32, and within the activation sleeve 8 , The second drive means 52 extends in the axial direction between the needle protection element 20 and the proximal end of the support housing 5, in particular the rear support housing part 32. the end wall of the connecting part 28 form a stop for the second drive means 52.
    It is expedient if the first drive means 26 and the second drive means 52 are each formed by a compression spring designed as a helical spring. This means that standard components can be used. This makes it possible to choose a slim design for the second drive means 52. Thus, the second drive means 52, which is designed as a helical spring, can be arranged on the side of the piston rods 23 in cross section opposite the receiving part 27 of the drive element 22 between the support housing 5 and the activation sleeve 8.
    In order to prevent the second drive means 52, which is preferably designed as a helical spring, from buckling, it can be guided at least in sections along its longitudinal extent by means of guide elements 53. The guide elements 53 can be arranged on an outer side of the support housing 5, in particular the front support housing part 31, and can be formed by webs or ribs.
    In order to avoid a stab injury from the cannulas 15, 16 used, the needle protection element 20 can be in its cover position in the proximal direction
    21/39
    N2016 / 28700 AT-00
    Direction and in the axial direction relative to the support housing 5 can be kept locked by means of a locking device, not shown.
    The performed with the activation sleeve 8 with respect to the support housing 5 axial adjustment causes the simultaneous release of both the first drive assembly 13 and the second drive assembly 21st
    In conclusion, it should also be pointed out that the above-described design of the injection device 1, in particular the auto-injector, corresponds in some component groups to the design that corresponds to a predecessor company of this applicant in WO 2009/152542 A1. For this reason, reference is made to the disclosure contained in WO-A1 for the formation of the needle arrangement 17, the guidance and locking of the needle protection element 20 and the cartridges 9, 11.
    The exemplary embodiments show possible design variants, it being noted at this point that the invention is not limited to the specially illustrated design variants of the same, but rather also various combinations of the individual design variants with one another are possible and this variation possibility is based on the teaching of technical action through the present invention Ability of the specialist working in this technical field.
    The scope of protection is determined by the claims. However, the description and drawings are to be used to interpret the claims. Individual features or combinations of features from the different exemplary embodiments shown and described can represent independent inventive solutions. The object on which the independent inventive solutions are based can be found in the description.
    All information on value ranges in the objective description is to be understood so that it includes any and all sub-areas, e.g. the information 1 to 10 is to be understood so that all sub-areas, starting from
    22/39
    N2016 / 28700-AT-00 are also covered by the lower limit 1 and the upper limit 10, i.e. all sections start with a lower limit of 1 or greater and end with an upper limit of 10 or less, e.g. 1 to 1.7, or 3.2 to 8.1, or 5.5 to 10.
    For the sake of order, it should finally be pointed out that, for a better understanding of the structure, elements have sometimes been shown to scale and / or enlarged and / or reduced.
    23/39
    N2016 / 28700 AT-00
    LIST OF REFERENCE NUMBERS
    injection device 31 front supporting housing part person 32 rear support housing part distal end section 33 front recording room proximal end section 34 rear recording room support housing 35 connecting portion distal end 36 coupling device proximal end 37 Guide extension activating sleeve 38 opening carpule 39 sealing plug piston 40 sealing element carpule 41 sealing attachment Piston, 42 face first drive assembly 43 face safety device 44 Retention hook cannula 45 longitudinal axis cannula 46 partition needle assembly 47 recess first end of the cannula 48 safety cap second cannula end 49 safety pin Needle protection element 50 end wall second drive assembly 51 release means driving element 52 second drive means piston rod 53 guide element
    Piston rod first end region first drive means receiving part connecting part second end region holding device
    24/39
    N2016 / 28700 AT-00
    权利要求:
    Claims (27)
    [1]
    claims
    1. Injection device (1), in particular an auto-injector, which is designed to dispense at least two medications at the same time and is designed to be automatically adjustable from a storage position into an injection position, the injection device (1) has a distal end section (3) that can be turned towards a person (2) ) and a proximal end section (4) turned away from it and comprises a support housing (5), which support housing (5) is sleeve-shaped and has a distal end (6) and a proximal end (7), an activation sleeve (8), which Activation sleeve (8) surrounds the support housing (5) for the most part along its longitudinal extent, starting from the proximal end (7) towards the distal end (6), the distal end (6) of the support housing (5) surrounding the activation sleeve (8 ) and the activation sleeve (8) is adjustable in the axial direction relative to the support housing (5), at least one carpule (9, 11) with a piston (10, 12) arranged therein and adjustable in the axial direction and with a medicament which is received in the at least one cartridge (9, 11) and is to be dispensed during the injection process, the at least one cartridge (9, 11) in the carrier housing (5 ), a first drive assembly (13) with a first drive means (26), which first drive assembly (13) is in drive connection with the at least one carpule (9, 11) and the first drive assembly (13) by means of the activation sleeve (8) can be triggered, a securing device (14), which secures the first drive assembly (13) in position until it is activated for the injection process with respect to the support housing (5), a needle arrangement (17) with at least one cannula (15,) 16), which needle arrangement (17) is arranged in the storage position of the injection device (1) of the at least one carpule (9, 11) in the section of the distal end (7) and each both cannula ends (18, 19) of the at least one cannula (15,
    25/39
    N2016 / 28700 AT-00
    16) are arranged within the carrying housing (5), a needle protection element (20), which needle protection element (20) can be moved from a release position in the storage position to a cover position, in which cover position the after the injection process via the distal end (7) of the The cannula end (18) protruding from the support housing (5) and covering at least one cannula (15, 16), a second triggerable drive assembly (21) with a second drive means (52), which second drive assembly (21) does not remove the needle guard element (20) active position in the cover position, characterized in that at least two carpules (9, 11) are provided and the at least two carpules (9, 11) are arranged next to one another in cross section in the support housing (5), that the first drive assembly (13) furthermore has a drive element (22), which drive element (22) is arranged within the support housing (5), that the drive element (22) each have the same number of piston rods (23, 24) as the number of cartridges (9, 11), and the piston rods (23, 24) form a unit that belongs together such that at least one of the piston rods (23, 24) is designed as a hollow cylinder and at its first end region (25) facing the distal end section (3), the first drive means (26) is closed in the at least one hollow cylindrical piston rod (23, 24) and / or the first drive means (26) is in one seen in cross-section laterally next to the piston rods (23, 24) arranged receiving part (27) of the drive element (22) is arranged and the receiving part (27) with the piston rods (23, 24) forms a related unit.
    [2]
    2. Injection device (1) according to claim 1, characterized in that each of the at least two cartridges (9, 11) each has its own cannula (15,
    16) is upstream.
    26/39
    N2016 / 28700 AT-00
    [3]
    3. Injection device (1) according to claim 1 or 2, characterized in that the drive element (22) has a connecting part (28), by means of which connecting part (28) the piston rods (23, 24) and optionally the receiving part (27) in their the proximal end section (4) facing second end regions (29) are connected to each other and the piston rods (23, 24) and optionally the receiving part (27) protrude from the connecting part (28) in the distal direction.
    [4]
    4. Injection device (1) according to one of the preceding claims, characterized in that the piston rods (23, 24) and the receiving part (27) are each formed in a hollow cylinder shape and are closed in their first end regions (25) facing the distal end section (3) are trained.
    [5]
    5. Injection device (1) according to one of the preceding claims, characterized in that only one of the pistons (10) one of the preceding claims) of a first of the at least two cartridges (9) with the piston rod (10) associated with the piston rod (23) and the further one of the at least two carpules (11) is held on the first carpule (9) by means of a holding device (30).
    [6]
    6. Injection device (1) according to one of claims 1 to 4, characterized in that each of the pistons (10, 12) is coupled to the piston rod (23, 24) respectively associated therewith and the at least two cartridges (9, 11) independently are held from each other on the drive element (22).
    [7]
    7. Injection device (1) according to one of the preceding claims, characterized in that the carrier housing (5) comprises a front carrier housing part (31) with a front receiving space (33) and a rear carrier housing part (32) with a rear receiving space (34), and the two Tragge27 / 39
    N2016 / 28700-AT-00 housing parts (31, 32) can be coupled to one another in a connecting section (35) in the axial direction in two different longitudinal positions in a first connecting position and a second connecting position.
    [8]
    Injection device (1) according to claim 7, characterized in that the two support housing parts (31, 32) can be coupled to one another in the connecting section (35) via a coupling device (36).
    [9]
    9. Injection device (1) according to claim 7 or 8, characterized in that the rear support housing part (32) has at least two guide extensions (37) projecting in the distal direction, which guide extensions (37) are supported on the front support housing part (31).
    [10]
    10. Injection device (1) according to one of claims 7 to 9, characterized in that the support housing parts (31, 32) have a larger longitudinal extension in the first connection position with respect to the second connection position.
    [11]
    11. Injection device (1) according to one of claims 7 to 10, characterized in that the front support housing part (31) has a longitudinal extent in the axial direction, which has a value with a value with a lower limit of 60% and a value with an upper Limit of 95%, in particular with a value with a lower limit of 70% and a value with an upper limit of 85%, based on the total longitudinal extent of the two support housing parts (31) is selected in their second connection position.
    [12]
    12. Injection device (1) according to one of the preceding claims, characterized in that the distal end (7) of the support housing (5), in particular the distal end (7) of the front support housing part (31), one of the number of cannulas (15, 16) has the same number of openings (38), which openings
    28/39
    N2016 / 28700-AT-00 (38) allow the distal cannula ends (18) of the cannulas (15, 16) to pass through, and a pierceable sealing plug (39) is arranged in the sealing position in each of the openings (38).
    [13]
    13. Injection device (1) according to one of the preceding claims, characterized in that a sealing element (40) is provided, which sealing element (40) is arranged between the front carrier housing part (31) and the rear carrier housing part (32) and is formed continuously over the circumference is.
    [14]
    14. Injection device (1) according to claim 13, characterized in that the sealing element (40) on its distal end section facing the front support housing part (31) has a sealing projection (41) which extends over the entire circumference, which sealing projection (41) in the first Connection position of the two support housing parts (31) is arranged at a distance from an end face (42) of the front support housing part (31) and the sealing projection (41) in the second connection position of the two support housing parts (31, 32) sealingly on the end face (42) of the front support housing part (31) is present.
    [15]
    15. Injection device (1) according to claim 14, characterized in that the sealing projection (41) of the sealing element (40) is supported on an end face (43) of the rear supporting housing part (32) facing the front supporting housing part (31) and further the sealing element (40) extends into the rear support housing part (32).
    [16]
    16. Injection device (1) according to one of claims 13 to 15, characterized in that the sealing element (40) in the storage position and in the second connecting position located support housing parts (31, 32) both on the rear support housing part (32) and on the drive element (22) arranged inside the same, in particular its connecting part (28), of the first drive assembly (13) lies tightly around its circumference.
    29/39
    N2016 / 28700 AT-00
    [17]
    17. Injection device (1) according to one of the preceding claims, characterized in that the support housing (5), in particular the rear support housing part (32), has at its distal end a transverse wall (46) with a locking recess (47) arranged therein.
    [18]
    18. Injection device (1) according to one of the preceding claims, characterized in that the securing device (14) comprises at least one retaining hook (44), which at least one retaining hook (44) on the drive element (22), in particular its connecting part (28), arranged and the at least one retaining hook (44) is held in the storage position in the latching recess (47) of the transverse wall (46).
    [19]
    19. Injection device (1) according to one of the preceding claims, characterized in that the securing device (14) has a securing cap (48) arranged in the distal end section (3) with a securing pin (49), and the securing pin (49) of the at least one Retaining hook (44) is held in the locked position in the storage position.
    [20]
    20. Injection device (1) according to one of the preceding claims, characterized in that the activation sleeve (8) has an end wall (50) in its proximal end region, on which end wall (50) a release means (51), in particular a release opening, is arranged, which release means (51) is aligned in axial direction with respect to the latching recess (47) arranged in the transverse wall (46) of the support housing (5), in particular the rear support housing part (32).
    [21]
    21. Injection device (1) according to one of the preceding claims, characterized in that the second drive means (52) of the second drive assembly (21) outside of the support housing (5), in particular outside of the two support housing parts (31, 32), and within the activation sleeve (8) is arranged.
    30/39
    N2016 / 28700 AT-00
    [22]
    22. Injection device (1) according to one of the preceding claims, characterized in that the second drive means (52) of the second drive assembly (21) in the axial direction between the needle guard element (20) and the proximal end of the support housing (5), in particular the rear Support housing part (32) extends.
    [23]
    23. Injection device (1) according to one of the preceding claims, characterized in that the first drive means (26) and / or the second drive means (52) are each formed by a compression spring designed as a helical spring.
    [24]
    24. Injection device (1) according to one of the preceding claims, characterized in that the second drive means (52) on the receiving part (27) of the drive element (22) in cross-section side of the piston rods (23) is arranged.
    [25]
    25. Injection device (1) according to one of the preceding claims, characterized in that the second drive means (52) is guided in its longitudinal extent at least in sections by means of guide elements (53), the guide elements (53) on an outside of the support housing (5), in particular of the front support housing part (31).
    [26]
    26. Injection device (1) according to one of the preceding claims, characterized in that the needle protection element (20) is held locked in its covering position in the proximal direction and in the axial direction relative to the support housing (5).
    [27]
    27. Injection device (1) according to any one of the preceding claims, characterized in that with the axial adjustment of the activation sleeve (8) relative to the support housing (5), the simultaneous release of both
    31/39
    N2016 / 28700-AT-00 first drive assembly (13) and the second drive assembly (21).
    32/39
    N2016 / 28700 AT-00
    Pharma Consult Ges.m.b.H.
    33/39
    40.41
    Pharma Consult Ges.m.b.H.
    34/39
    OM
    40, 41
    Pharma Consult Ges.m.b.H.
    36/39 οο
    -J ·
    13, 26
    Pharma Consult Ges.m.b.H.
    37/39
    Pharma Consult
    Ges.m.b.H
    38/39
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    同族专利:
    公开号 | 公开日
    AT519383B1|2018-09-15|
    WO2018078121A1|2018-05-03|
    ES2867881T3|2021-10-21|
    EP3532129B1|2021-01-20|
    RU2764869C2|2022-01-21|
    IL266203D0|2019-06-30|
    ZA201903190B|2021-08-25|
    EP3532129A1|2019-09-04|
    US20220040409A1|2022-02-10|
    US20190262539A1|2019-08-29|
    CN110035784A|2019-07-19|
    CN113730730A|2021-12-03|
    CA3040594A1|2018-05-03|
    KR20190082816A|2019-07-10|
    RU2019113034A3|2020-11-27|
    JP2019532749A|2019-11-14|
    AU2017348622A1|2019-05-23|
    SG11201903156SA|2019-05-30|
    RU2019113034A|2020-11-27|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    ATA50987/2016A|AT519383B1|2016-10-27|2016-10-27|Injection device, in particular autoinjector, for the simultaneous delivery of several drugs|ATA50987/2016A| AT519383B1|2016-10-27|2016-10-27|Injection device, in particular autoinjector, for the simultaneous delivery of several drugs|
    CN201780066659.9A| CN110035784A|2016-10-27|2017-10-27|For the injection device that several drugs are administered simultaneously, especially automatic injector|
    PCT/EP2017/077651| WO2018078121A1|2016-10-27|2017-10-27|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
    KR1020197015059A| KR20190082816A|2016-10-27|2017-10-27|For simultaneous administration of various drugs, in particular automatic syringes, scanning devices|
    US16/345,823| US20190262539A1|2016-10-27|2017-10-27|Injection Device, In Particular Autoinjector, for the Simultaneous Administration of Several Medications|
    RU2019113034A| RU2764869C2|2016-10-27|2017-10-27|Injection device, in particular a syringe pen, for the simultaneous administration of several drug preparations|
    JP2019522397A| JP2019532749A|2016-10-27|2017-10-27|Injection device for simultaneous administration of several drugs, especially automatic syringes|
    ES17792033T| ES2867881T3|2016-10-27|2017-10-27|Injection device, in particular autoinjector, for the simultaneous administration of several drugs|
    CA3040594A| CA3040594A1|2016-10-27|2017-10-27|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
    EP17792033.7A| EP3532129B1|2016-10-27|2017-10-27|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
    AU2017348622A| AU2017348622A1|2016-10-27|2017-10-27|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
    CN202110967970.9A| CN113730730A|2016-10-27|2017-10-27|Injection device, in particular autoinjector, for the simultaneous administration of several medicaments|
    SG11201903156SA| SG11201903156SA|2016-10-27|2017-10-27|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
    IL266203A| IL266203D0|2016-10-27|2019-04-23|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
    ZA2019/03190A| ZA201903190B|2016-10-27|2019-05-21|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
    US17/510,888| US20220040409A1|2016-10-27|2021-10-26|Injection device, in particular autoinjector, for the simultaneous administration of several medications|
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